The ectoplasmic specialization (ES) is a testis‐specific, actin‐based hybrid anchoring and tight junction. It is confined to the interface between Sertoli cells at the blood–testis barrier, known as the basal ES, as well as between Sertoli cells and developing spermatids designated the apical ES. The ES shares features of adherens junctions, tight junctions and focal contacts. By adopting the best features of each junction type, this hybrid nature of ES facilitates the extensive junction‐restructuring events in the seminiferous epithelium during spermatogenesis. (...) For instance, the α6β1‐integrin–laminin 333 complex, which is usually limited to the cell–matrix interface in other epithelia to facilitate cell movement, is a putative apical ES constituent. Furthermore, JAM‐C and CAR, two tight junction integral membrane proteins, are also components of apical ES involving in spermatid orientation. We discuss herein the mechanisms that maintain the cross‐talk between ES and blood–testis barrier to facilitate cell movement and orientation in the seminiferous epithelium. BioEssays 29: 36–48, 2007. © 2006 Wiley Periodicals, Inc. (shrink)

Este trabajo presenta seis ponencias en torno a los problemas que atraviesan distintos sectores de la población en situación de vulnerabilidad social en el goce de sus derechos humanos en el contexto de la pandemia global de COVID-19. Las exposiciones reflexionan sobre los prejuicios y vulnerabilidades que atraviesan las personas adultas mayores; las violencias de género en contextos de aislamiento; las personas en contextos de movilidad excluidas de las medidas de protección; el tratamiento y priorización de las personas con discapacidad (...) en los centros de derivación de COVID-19; la protección de las garantías penales en la administración de justicia durante los juicios de lesa humanidad llevados en forma remota; y el avance de las causas por crímenes de lesa humanidad durante la pandemia. (shrink)

Segun Levinas la temporalidad es imprescindible para lograr una auténtica apertura de la inmanencia. En buen medida, esta convicción se inspira de la noción husserliana de Urimpression. Sin embargo, despuès de hacer pie en la fenomenologia husserliana, Levinas propone proseguir un poco mas allà, planteando la necessidad de considerar un tiempo completamento desligado de la conciencia: el tiempo diacronico. En el intento de abrirse a la tracendencia, Levinas sustituye la intencionalidad de la conciencia por la temporalidad diacronica porque solo esta (...) ultima permite una verdadera relación con la trascendencia sin reducirla a inmanencia. Selon Levinas, la temporalité est indispensable pour parvenir à une ouverture authentique sur l'immanence. Cette conviction s'inspire en grande partie de la notion husserlienne d'Urimpression. Toutefois, après s'être appuyé sur la phénoménologie husserlienne, Levinas propose d'aller un peu plus loin en posant la nécessité de prendre en considération un temps complètement détaché de la conscience : le temps diachronique. Pour s'ouvrir à la transcendance, Levinas substitue à l'intentionnalité husserlienne la temporalité diachronique qui seule permet une véritable relation à la transcendance sans la réduire à l'immanence. According to Levinas, temporality is indispensable for an authentic opening onto immanence. This conviction is largely inspired by the Husserlian concept of Urimpression. However, after accepting Husserl's phenomenology as the point of departure, Levinas proposes to go a little further by postulating the need to consider time as completely detached from consciousness: i.e. diachronic time. In order to become open to transcendence, Levinas substitutes for Husserlian intentionality a diachronic temporality, which alone would allow a true relationship with transcendence unreduced to immanence. (shrink)

O presente artigo tem por objectivo fazer uma reflexão sobre o motto, o prólogo e a introdução a O conceito de Angústia (1844) de Søren Kierkegaard. Longe de serem meros preâmbulos, estes textos constituent importantes chaves de leitura para a obra que encabeçam. Na verdade, a distinção socrática entre o que se sabe e o que não se sabe do motto de O conceito de angústia transforma-se no argumento propriamente dito da obra. A partir desta distinção, Kierkegaard desenvolve a sua (...) crítica contra a confusão moderna das ciências, ao mesmo tempo que propõe uma nova divisão em ordem a poder situar legitimamente a questão do pecado. Em vez de conceber o pecado de maneira especulativa, a psicologia da angústia é apresentada como a única disciplina em que propriamente se pode tratar o problema do pecado e, ao mesmo tempo, ser consciente da sua incompreensibilidade. /// The objective of this article is to think about the motto, preface and introduction to Kierkegaard's The Concept of Anxiety (1844). Far from being mere preambles, these texts constitute the reading key for the book they lead. As a matter of fact, the Socratic distinction between what we understand and what we do not understand from The concept of Anxiety's motto becomes the philosophical argument of the work. From this distinction, Kierkegaard carries out a critique against the modern confusion of sciences and at the same time proposes a new arrangement in which to place legitimately the problem of sin. Instead of conceiving sin in a speculative way, the psychology of anxiety shows itself to be the only discipline able to deal properly with the question of sin and to be conscious of its mysterious dimension. (shrink)

Objectives To develop and test two educational programmes (interactive and passive) aimed at improving family doctors' (FD) prescribing practices and patient's knowledge and use of non-opioid analgesics (NOA).Methods The educational programmes were conducted in two family medicine clinics by using a three-stage approach: baseline evaluation, design, and implementation of educational activities, and post-programme evaluation. An interactive educational programme (IEP) was compared with a passive educational programme (PEP); both were participated by FDs and patients. The IEP for FDs comprised of workshops, (...) discussion groups, in-service training and guidelines, while for patients the IEP consisted of an interactive session with a video, leaflets and a discussion. The PEP consisted in delivering the guidelines to the FDs and the leaflets to patients. The effect of the programmes on the FDs was measured through the appropriateness of prescriptions and analysed using the differences-in-differences estimator (D-in-D), and on patients through changes in self-medication and in their knowledge about the proper use and adverse events by analysing the inter- and intra-group differences before and after the programmes.Results The IEP obtained better results to improve appropriate FDs prescription of NOA than PEP (D-in-D = 15%). Regarding the patients, the PEP group reached higher reduction of self-medication than the IEP group (13.4% vs. 9.1%); the knowledge of proper NOA use increased by 8.5% in both groups, whereas knowledge of NOA-related adverse events was better in the IEP (39.6%) than in the PEP group (9.2%).Conclusions The IEP was better to improve the doctors' abilities to prescribe NOAs, and both programmes improved patients' knowledge. (shrink)

Introduction: Publications arguing against the null hypothesis significance testing (NHST) procedure and in favor of good statistical practices have increased. The most frequently mentioned alternatives to NHST are effect size statistics (ES), confidence intervals (CIs), and meta-analyses. A recent survey conducted in Spain found that academic psychologists have poor knowledge about effect size statistics, confidence intervals, and graphic displays for meta-analyses, which might lead to a misinterpretation of the results. In addition, it also found that, although the use of ES (...) is becoming generalized, the same thing is not true for CIs. Finally, academics with greater knowledge about ES statistics presented a profile closer to good statistical practice and research design. Our main purpose was to analyze the extension of these results to a different geographical area through a replication study. Method: For this purpose, we elaborated an on-line survey that included the same items as the original research, and we asked academic psychologists to indicate their level of knowledge about ES, their CIs, and meta-analyses, and how they use them. The sample consisted of 159 Italian academic psychologists (54.09% women, mean age of 47.65 years). The mean number of years in the position of professor was 12.90 (SD = 10.21). Results: As in the original research, the results showed that, although the use of effect size estimates is becoming generalized, an under-reporting of CIs for ES persists. The most frequent ES statistics mentioned were Cohen’s d and R2/η2, which can have outliers or show non-normality or violate statistical assumptions. In addition, academics showed poor knowledge about meta-analytic displays (e.g., forest plot and funnel plot) and quality checklists for studies. Finally, academics with higher-level knowledge about ES statistics seem to have a profile closer to good statistical practices. Conclusions: Changing statistical practice is not easy. This change requires statistical training programs for academics, both graduate and undergraduate. (shrink)

Background:Women's health has received renewed attention in the last few years including health rehabilitation options for women affected by breast cancer. Dancing has often been regarded as one attractive option for supporting women's well-being and health, but research with women recovering from breast cancer is still in its infancy. Dancing with Health is multi-site pilot study that aimed to evaluate a dance programme for women in recovery from breast cancer across five European countries.Methods:A standardized 32 h dance protocol introduced a (...) range of Latin American dances presented within a sports and exercise framework with influences from dance movement therapy. Fifty-four women (M age 53.51; SD 7.99) participated in the study who had a breast cancer diagnosis 6 weeks, no indication of metastasis, or scheduled surgery/chemotherapy/radiation treatment for the duration of the intervention. Primary outcome data was collected for anthropometric and fitness measures next to cancer-related quality of life.T-tests and Wilcoxon signed ranked tests were used to establish differences pre and post intervention. Cohen's d was also calculated to determine the effect size of the intervention.Results:Statistically significant changes were found for: (i) weight, right and left forearm circumference and hip; (ii) 6 min walking, right and left handgrip, sit-to-stand and sit-and-reach; (iii) the EORTC-QLQ C30 summary score as well as the subscales of emotional and social functioning and symptoms. In all cases the direction of change was positive, while Cohen's d calculated showed that the effect of the intervention for these parameters ranged from intermediate to large.Conclusion:Changes on the above anthropometric, fitness and quality of life measures suggest that the intervention was of value to the participating women recovering from breast cancer. Results also advocate collaborative efforts across countries to further research. (shrink)

Dolores Dooley Clarke describes how the course in medical ethics at University College, Cork is structured, how it has changed and how it is likely to change as time goes on. Originally, the students seemed to view it as an intrusion 'to be tolerated' in their programme of 'strictly medical' studies. However, having moved on from that and away from the lecturer always being a Roman Catholic priest as well as a member of the Philosophy Department, the students now (...) appear to view it as producing a stimulus for a new interest in the area of ethics for physicians. This seems to have come about through the more extensive participation of students in researching and presenting issues of medical ethics. (shrink)

[…]Per nostra tranquillità – gli animali non muoionoma crepano d’una morte per così dire più piatta,perdendo – vogliamo crederlo – meno sensibilità e mondo,uscendo – così ci pare – da una scena meno tragica.Le loro animucce mansuete non ci ossessionano la notte,mantengono la distanza,conoscono i mores. E così questo scarabeo morto sul viottolobrilla non compianto verso il sole.Basta pensarci per la durata di uno sguardo:sembra che non gli sia accaduto nulla di importante.L’importante, pare, r...

« No pasaran » (ils ne passeront pas). Devant les micros del Ministerio de Gobernacion, la députée communiste Dolorès Ibarruri officialise le mot d’ordre destiné à unir les forces de gauche contre les rebelles fascistes. En ce 19 juillet 1936, au lendemain du coup d’Etat nationaliste, les défenseurs de la démocratie viennent de trouver leur cri de ralliement ; une femme, qui devient un mythe, incarne la lutte. Les facettes de cette construction imaginaire se dévoilent aisément : voix du peup..

« No pasaran » (ils ne passeront pas). Devant les micros del Ministerio de Gobernacion, la députée communiste Dolorès Ibarruri officialise le mot d’ordre destiné à unir les forces de gauche contre les rebelles fascistes. En ce 19 juillet 1936, au lendemain du coup d’Etat nationaliste, les défenseurs de la démocratie viennent de trouver leur cri de ralliement ; une femme, qui devient un mythe, incarne la lutte. Les facettes de cette construction imaginaire se dévoilent aisément : voix du peup...

E n e s t e a r t í c u l o s o n d e a r é , t a n t ol a c a n a l i z a c i ó n d e l d o l o r c o mo e lest ancami ent o del suf ri mi ent o en l ospensami ent os de Schopenhauer y DeQuincey, respectivamente. En el caso delliterato inglés veremos que es (...) opuestoen términos éticos al desenlace vivencialtanto de la conciencia mej or, como lanegación de la voluntad de vivir, puestoque, mientras los placeres del opio fluyentras sueños que se transforman en terriblessufrimientos, el dolor en Schopenhaueres sublimado hasta ser convertido en elδεύτερος πλοῦς de su ética.In this paper, I shall explore the channelingof pain and the blockage of suffering inthe thoughts of Schopenhauer and DeQuincey respectively. In the case of theEnglish writer, I shall show that his view isopposite in ethical terms to the existentialoutcome both of the better conscienceand of the denial of the will to live, sincewhile the pleasures of the opium flow afterdreams that are transformed into terriblesufferings, the pain, in Schopenhauer, issublimated until it is transformed in theδεύτερος πλοῦς of his ethics. (shrink)

In 2022, at an interdisciplinary conference on Creation and the Imago Dei, Biola psychologist Liz Hall posed a powerful challenge to the philosophers and theologians in the room. In the face of the “already and not yet” nature of Christian theology, she put forth the need for a “theology of tension.” Over and over again, while reading Biblical Philosophy, I was reminded of this challenge. The features Johnson puts forth as emblematic of Hebraic Philosophy can help in this respect, in (...) two clear ways: First, retrospectively, Johnson’s categories are useful for diagnosing both the philosophical missteps targeted by critiques of theodicy and the features held in common by some of the more successful accounts. Second, going forward, the convictions and modes of argument central to Hebraic philosophy may help guide future philosophical responses to suffering. In general, I believe that the philosophical problems related to suffering are especially well-suited to responses that are pixelated, networked, mysterianist, creationist, transdemographic, and ritualist. Perhaps Hebraic philosophy can succeed where Hellenist philosophy has struggled: in addressing the tension that arises from the experience of suffering in a world governed by a loving, providential, sovereign God. While I am largely in favor of Johnson’s Hebraic philosophy, I will conclude by breaking from his view in one important respect. Johnson presents the Biblical view as substantially contrasting with the correspondence theory affirmed by many contemporary philosophers. I will end by pushing back on this claim. On Johnson’s own account, the Hebraic notion of truth is determined with reference to the divinely designed order. I propose that we understand the Hebraic notion of truth as degrees of correspondence to this divinely ordered, absolute reality. (shrink)

Ce livre co-rédigé par deux historiennes des universités espagnoles de Valence et Málaga, correspond à la fois à une exigence pédagogique et à une ambition scientifique : l’approche, pour un public universitaire (la collection est placée sous la direction de Elena Hernández Sandoica) d’une période a priori très documentée : la fin de la Monarchie des Bourbons - règne d’Alphonse XIII et dictature de Primo de Rivera - la Seconde République et la guerre d’Espagne. Mais la lecture proposée ici es...

Christie is a member of the Department of Religious Studies at Baldwin-Wallace College, Cleveland, Ohio (U.S.A.).

Although the importance of operational definitions is obvious while researching new areas of work, taking time to define terms, especially key ones, is also important for mature fields. The study of self-esteem, for instance, is one of the oldest themes in psychology and it is characterized by work based on at least three different definitions of selfesteem. Each one of them has given rise to a school of thought with its own body of supportive research and findings. Such situations often (...) generate confusion in a field, especially when it comes to establishing consensus or integrating material. Thus, this article first presents the two-factor approach to self-esteem in order to demonstrate how defining it as a relationship between competence and worthiness helps to resolve issues that other leading definitions do not, especially the common practice of defining self-esteem simply as a feeling of “worth.” Second, an attempt is made to show how a two-factor approach also better integrates work on the cognitive and affective of dimensions of self-esteem. (shrink)

Erik Wielenberg recently invoked the parent-child analogy in an argument against Christian theism. The argument relies on the claim that a loving parent would never allow her child to feel abandoned in the midst of what feels like gratuitous suffering. In this paper, I offer three clear counterexamples to Wielenberg’s central premise. At the same time, a successful counterexample does not a robust theology of suffering make. To that end, and with a careful eye towards anti-theodical concerns, I defend the (...) need for a more proactive Christian philosophical examination of the role of suffering in a meaningful life. (shrink)

One of Hume's most well-known works and a masterpiece of philosophy, A Treatise of Human Nature is indubitably worth taking the time to read.

Son diversos los motivos que justifican analizar, de forma separada, la depresión y los trastornos de ansiedad en personas mayores con respecto a adultos más jóvenes. Podemos enumerar, entre los más relevantes, los siguientes: (1) sintomatología diferencial que puede dificultar el diagnóstico en la vejez; (2) infradeclaración clínica, consecuencia del efecto negativo de los estereotipos de la edad sobre la población mayor y los profesionales que los tratan; (3) mayor cronificación de los síntomas, debido a un posible diagnóstico tardío; (4) (...) mayor impacto funcional, ya que ambos trastornos se pueden asociar a diversas patologías, como anemia o diabetes (en la depresión) o presión arterial, úlcera o problemas cardiovasculares ( en la ansiedad), produciéndose una interacción recíproca entre la sintomatología psicológica y física que exacerba ambos tipos de problemáticas. (shrink)

Que la población mayor está bien ajustada emocionalmente es algo bien constatado en la investigación gerontológico. Este dato, puesto en relación con otros, genera una curiosa consecuencia: la denominada "Paradoja del bienestar en la vejez". Con la edad, junto al aumento de circunstancias relativas a pérdidas (de parientes, amigos, funcionamiento físico y roles sociales) se da una estabilidad en las puntuaciones de diversos indicadores de bienestar psicológico (expresión de emociones positivas, prevalencia de trastornos depresivos o ansiedad). Los aspectos explicativos que (...) se esgrimen para despejar esta paradoja son, entre otros, la mejora de mecanismos de autorregulación emocional y el carácter gradual y normativo de dichas pérdidas (Márquez-González, 2008 y Fernández-Ballesteros, 2009). (shrink)

This article discusses the Australian government’s immigration policies in the context of the global refugee crisis in the years 2015–2016, as reflected and dramatised through the polemical novel b...

O artigo ten como obxectivo facer un percorrido por tres momentos da escritura filosófica no que o fenómeno do límite ou fronteira do pensamento se pon claramente de manifesto no discurso. En primeiro lugar, Kant, como artífice da produtiva noción dunha “fronteira [Grenze]” da razón como condición e límite do pensamento; en segundo lugar, Hegel, como o seu máximo crítico na “asunción [Aufhebung]” da negación da fronteira kantiana; e, finalmente, Kierkegaard, cuxa contribución á discusión dos seus predecesores consiste no “pathos (...) [Lidenskab]” do límite que Kant demarca e Hegel supera, pois no caso do pensador dinamarqués o límite da filosofía é ao mesmo tempo paradoxo, é dicir, algo que non pode ser coñecido senón tan só re-coñecido pola razón e que pon xustamente a razón no seu límite. (shrink)

Mathematics educators suggest that students of all ages need to participate in productive forms of mathematical argument (NCTM, 2000). Accordingly, we developed two complementary frameworks for analyzing the emergence of mathematical argumentation in one second‐grade classroom. Children attempted to resolve contesting claims about the “space covered” by three different‐looking rectangles of equal area measure. Our first analysis renders the topology of the semantic structure of the classroom conversation as a directed graph. The graph affords clear “at a glance” visualization of (...) how various senses of mathematics—as imagined, as performed, and as historically rooted—were interrelated. The graph represents the emergence and intercoordination between conceptual and procedural knowledge in the ebb and flow of classroom conversation. The graph has not just descriptive, but also predictive power: Interconnectedness among the nodes of the graph representing the first 40 min of conversation predicted the structure of recall in the final ten minutes by children who had played little overt role in the conversation up to that point. The second, complementary framework draws upon Goffman's expanded repertoire of roles in speech to demonstrate how the teacher orchestrated this classroom conversation to establish coherent argument. In this second analysis, we establish how the teacher mediated between the everyday talk of her students and the discourse of mathematics. Her revoicing of student talk created interstices for identity and participation in the formation of the argument. Together, the two forms of analysis illuminate the emergence of mathematical argument at two levels: as collective structure and concurrently, as individual activity. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Changing Human Nature: Ecology, Ethics, Genes, and God by James C. PetersonDolores L. ChristieChanging Human Nature: Ecology, Ethics, Genes, and God James C. Peterson Grand Rapids, Mich.: Eerdmans, 2010. 259 pp. $18.00Grounding himself in the Christian tradition, James Peterson argues for the moral efficacy of human genetic manipulation. Interpreting intentional intervention as part of human stewardship rather than as a wrongful interference with some divine plan, he takes (...) on the sticky questions, making critical distinctions, for example, between cure and enhancement or welcoming children as they come and making them “better.” Not neglecting future implications of current tinkering with human biology, even in such taboo areas as gamete selection, he contends that engineering a baby free of harmful genes (for example, Tay-Sachs or Down syndrome) not only makes that person better, but it also eliminates an ongoing burden to family, to society, and perhaps to future generations. Treading gingerly among the sacred cows of some Christian ethicists, he advocates the implanting of selected embryos free of unwanted genes; in his view, embryos are not yet persons.Peterson considers serious concerns such as eugenics projects and racial bias but offers standards to address them. He contends that intentionally increasing choices for our children is not only acceptable but also praiseworthy. What parents would not optimize the educational and social opportunities for their child, even without the child’s consent? Interventions should be safe, offer genuine improvement, increase the recipient’s capacity, and make the best use of limited resources. Peterson is not so naive that he does not recognize that technology does not always make us better. He recognizes, too, that his standards do not eliminate risk.Fair enough, but the issue of what “improvement” may mean to the individual as well as to the greater community remains somewhat ambiguous. Peterson suggests that broadening the decision making among a variety of professional and individual cohorts would help, but his argument is not totally persuasive. In sum, Peterson’s treatment falls short of offering a totally satisfying standard for determining which characteristics should be manipulated and which should be accepted. Nor does he demonstrate definitively how a [End Page 187] Christian perspective would contribute to sorting out possible choices. Does the deaf parents’ desire for their child to be deaf like them constitute an instance where intervention should not be attempted? Can the disparate cohorts he suggests as arbiters rise above their own biases? Does Christianity and its belief system offer answers? Readers—even readers who call themselves Christian—will likely be persuaded that genetic intervention is a good, and even compatible with their religious perspective. Nonetheless, they will harbor lingering doubts about how the questions can best be solved, who should solve them, and how Christian belief helps sort among the possibilities. In his closing comments Peterson appears to agree.The book is rich in research and in provocative ideas. It is an exciting book. It is a readable and enlightened contribution to the professional conversation on gene therapy. Peterson’s research is extensive, his argumentation balanced. His attempt to locate the question within the Christian tradition is laudable. Happily, Peterson eschews a creationist approach to world and human origins. Unhappily, his approach to the scriptural text is not always nuanced. His assertion that Jesus himself was different biologically from other human beings (132) seems a stretch. If one takes the passages of Jesus’s biological origins literally, as apparently does the author, what happens to the assertion that Jesus is like other human beings “in all things but sin”? And where did Jesus get the Y chromosomes? While he persuades the reader that genetic intervention is compatible with a Christian worldview, Peterson does not offer—at least in this reviewer’s view—an adequate criterion for navigating this new world of the possible.Dolores L. ChristieJohn Carroll UniversityCopyright © 2013 Society of Christian Ethics... (shrink)

Research traditions on cognition and depression focus on relatively unconnected aspects of cognitive functioning. On one hand, the neuropsychological perspective has concentrated on cognitive control difficulties as a prominent feature of this condition. On the other hand, the clinical psychology perspective has focused on cognitive biases and repetitive negative patterns of thinking for emotional information. A review of the literature from both fields reveals that difficulties are more evident for mood-congruent materials, suggesting that cognitive control difficulties interact with cognitive biases (...) to hinder cognitive switching, working memory updating, and inhibition of irrelevant information. Connecting research from these two traditions, we propose a novel integrative cognitive model of depression in which the interplay between mood-congruent cognitive control difficulties, cognitive biases, and rumination may ultimately lead to ineffective emotion-regulation strategies to downregulate negative mood and upregulate positive mood. (shrink)

Biobanking in Europe has made major steps towards harmonization and shared standards for the collection and processing of data and samples stored in biobanks. Still, biobanks and researchers face substantial legal difficulties in the field of data protection and sample management. Data protection law was harmonized almost 15 years ago while rights in samples fall under the competence of the Member States of the EU. Despite the Data Protection Directive the field of data protection shows a substantial degree of deviation (...) as public health was excluded from the harmonization. Biobanks seem to have substantially fewer difficulties to cope with in terms of the legal requirements in the field of sample management. This paper discusses the legal framework, experiences of different biobanks in Europe and potential ways forward. It also highlights the need for a health economic analysis of the costs and benefits of privacy protection in Europe. At the moment, policymakers seem to build their decisions on an insufficient evidence base which underestimates the potential value of biobanks for European public health. Within the past few years little progress has been achieved with regards to the development of a unified legal framework in Europe, The diversity in the legal system is also reflected in the different approaches of ethics committees towards biobanking. To secure the responsible and effective use of data and samples, more efforts are needed to come up with pathways for a solution. (shrink)